Two young men are swimming naked in an Adirondack lake when they hear a motor, a car appears, and two women get out, one with an orange scarf around her head. It's 1936: New York is suffering through the Great Depression, frightening things are happening in Europe, and Artie Saltzman and Harold Abramovitz, friends since their Brooklyn childhood, are unsure about everything—jobs, lefty politics, women. After this time in the mountains, nothing will be quite the same.

From World War II to the McCarthy-era witch hunts, through work, marriages, and life with children, Artie and Harold turn to each other, whether for solace or another good argument. And when Artie's daughter Brenda comes of age during the 1960s, her struggles with jobs, love, and friendship in yet another period of political turmoil recall Artie and Harold's youth.

A sweeping yet intimate novel about people who never stop loving one another despite everything life throws at them, When We Argued All Night illuminates a friendship over more than sixty-five years, as the twentieth century gives way to the changed yet recognizable times in which we live.